Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases

S Hanessian; P W Sgarbi

doi:10.1016/s0960-894x(00)00021-4

Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases

Bioorg Med Chem Lett. 2000 Mar 6;10(5):433-7. doi: 10.1016/s0960-894x(00)00021-4.

Authors

S Hanessian¹, P W Sgarbi

Affiliation

¹ Department of Chemistry, Université de Montréal, Station Centre-ville, QC, Canada. hanessia@ere.umontreal.ca

PMID: 10743942
DOI: 10.1016/s0960-894x(00)00021-4

Abstract

A series of indanotriazine C-ribosides were prepared as SAH mimics, and tested for their ability to inhibit erythromycin resistance methylases Erm AM and Erm C'. A carbocyclic analogue derived from quinic acid was also synthesized and tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemical synthesis*
Indans / chemical synthesis*
Indans / pharmacology
Methyltransferases / antagonists & inhibitors*
Ribonucleosides / chemical synthesis*
Ribonucleosides / pharmacology
S-Adenosylhomocysteine / analogs & derivatives
S-Adenosylhomocysteine / chemistry*
S-Adenosylhomocysteine / pharmacology
Triazines / chemical synthesis*
Triazines / pharmacology

Substances

Enzyme Inhibitors
Indans
Ribonucleosides
Triazines
S-Adenosylhomocysteine
Methyltransferases
S-adenosylmethionine-erythromycin O-methyltransferase